Discovering if you are part of the 1%-5% of diabetics that has MODY can lead to changes in your disease management program

Diabetes usually involves a complex combination of environmental factors and genetics. MODY is different, a single genetic variant can drive the disease 1.

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9 out of 10 MODY patients are misdiagnosed (~500,000 people)

MODY is commonly misdiagnosed as Type 1 or Type 2 diabetes and can be uncovered at any age despite onset of disease usually occurring earlier in life 2-3.

Genetic testing is one of the best ways to find out if you are affected by MODY

Some signs of MODY can be diabetes diagnosis at a young age, diabetes despite a normal weight, and having a strong family history of diabetes.

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Test results may yield a major change in treatment recommendations, potentially eliminating the need for insulin therapy 2, 4-6
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Major treatment recommendations may also include changes in oral medication

In some cases, glucose levels can be controlled by diet and exercise alone.

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If someone is found to have a genetic variant that causes MODY, there is a 50% (or 1 in 2) chance that their parents, siblings, and children also inherited the same variation 7.

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The Inherited Diabetes Test Has Two Possible Outcomes

Regardless of results, consulting a doctor is recommended to discuss better managing your diabetes

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    No variant found No variants linked to MODY were found.
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    Pathogenic Likely pathogenic and pathogenic variants have very strong and definitive scientific evidence linking them with MODY. We recommend you consult with your physician or an endocrinologist, a specialist in diabetes, about managing your diabetes differently based on the results of this test.
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References

  1. National Institute of Diabetes and Digestive and Kidney Diseases. “Monogenic Forms of Diabetes.” Accessed July 22, 2017. (www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/monogenic-neonatal-mellitus-mody)
  2. Kleinberger J. et al. Undiagnosed MODY: Time for Action. Curr Diab Rep. Dec 2015; 15(12):110
  3. “Diabetes Research and Advocacy Fund (MODY)” A Project of Research. University of Maryland School of Medicine, N.d. Web. June 2017
  4. Pihoker C. Prevalence, characteristics and clinical diagnosis of maturiry onset diabetes of the young due to mutations in HNF1A, HNF4A, and Glucokinase: Results from the SEARCH for diabetes in youth. J Clin Endocrinol Metab. Oct 2013; 98(10):4055-4062
  5. Gardner D. et al. Clinical features and treatment of maturity onset diabetes of the young (MODY). Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2012:5 101-108
  6. Naylor R. et al. Who should have genetic testing for Maturity-onset Diabetes of the Young? Clin Endocrinol. 2011:75(4):422-426
  7. Thanabalasingham G. et al. Diagnosis and management of maturity onset diabetes of the young (MODY). BMJ. 2011;343:d6044