At Admera, we are committed to helping you improve your health.

Through our collaboration with Helix, and from only a small saliva sample, we will help you decipher your DNA and provide you with information to lead a healthier life and give you peace of mind.

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Inherited Cholesterol Test

High cholesterol can be the result of your genetics. About 1 in 250 people, over 800,000 adults in the US, have an inherited condition called familial hypercholesterolemia (FH). Fortunately, there are treatment options available and lifestyle adjustments you can make that can lower your cholesterol and prevent the risk of heart disease.

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Cardio Scout Test

Certain conditions that predispose people to diseases of the heart muscle or to life-threatening heart rhythms are genetic. They can appear suddenly and without symptoms. CardioScout is designed to screen for some of the most common forms of these genetic heart conditions.

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Inherited Diabetes Test

Type I and Type 2 diabetes are well known. A form of inherited diabetes called maturity onset diabetes of the young (MODY), while less common, is different and can be caused by a single gene. MODY is underdiagnosed but finding out if you have it can help you and your doctor better manage your disease.

How it works

Learn more about the process, the test, and the accuracy of the results
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STEP 1

Send us your saliva.

After a licensed physician approves your health survey, our partner, Helix, will send you a Helix DNA Kit. Just follow the simple instructions for providing a saliva sample and send it back.

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STEP 2

Helix sequences your DNA.

Within 4 to 6 weeks, your DNA will be sequenced at Helix’s CLIA- and CAP-accredited lab.

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STEP 3

Receive your report.

We let you know when your results are available and you can access them online at your convenience.

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STEP 4

Healthier passages to your life’s journal.

Whatever your results, we help you remain informed and engaged to live the healthiest life you can.

FAQ

  • What can the products within Admera Health’s Personal Portfolio tell me?

    You can learn if you have a variation in your DNA (mutation) that has some level of evidence of being disease causing for Familial Hypercholesterolemia, conditions associated with Sudden Cardiac Death, and Maturity Onset Diabetes of the Young.

    Familial Hypercholesterolemia: If you are concerned about high cholesterol or already have high cholesterol you may be at risk for an inherited disease which causes high levels of “bad” cholesterol (LDL-C), a well-established risk factor for heart disease. Over time, arteries exposed to bad cholesterol begin to narrow from accumulations of cholesterol (atherosclerosis) leading to a cardiovascular disease such as heart attacks and death.1

    Sudden Cardiac Death: You may be at risk for Sudden Cardiac Death as it is a common and devastating event occurring often in the prime of life. SCD out-of-hospital represents 60% of all cardiac deaths. Over 400,000 persons die from SCD annually in the US. Most SCDs occur in individuals without diagnosed cardiac disease or fitting other risk profiles.2

    MODY: You have a 2% chance that your diabetes is being caused by a genetic mutation on one of several genes and termed Maturity Onset Diabetes of the Young or MODY.3 Most cases of this type of inherited diabetes are misdiagnosed due to misclassification as either Type 1 or Type 2.4 Correctly identifying your type of diabetes has importance for treatment.3 After consultation with your physician and confirmation of the diagnosis of MODY, you may be able to get off your insulin therapy and/or may need to change your oral diabetes medications to achieve proper glucose control.

  • Will results also have meaning for my family members?

    If your results turn out positive, there is a strong chance that some of your family members will too. Most of the conditions screened for in Admera Health’s Personal Portfolio are autosomal dominant. With few exceptions, humans have 23 pairs of chromosomes, structures containing DNA that hold the genetic information that is passed down from one generation to the next. You receive half your chromosomes from your biological father and half from your biological mother. If a gene is on a chromosome that is not responsible for determine sex, it is considered autosomal. If only one copy of the gene is necessary for a genetic condition to occur, this is considered a dominant mutation. A parent with an autosomal dominant condition has a 50 percent chance of having an affected child with one mutated gene (dominant gene) and a 50 percent chance of having an unaffected child. In an autosomal recessive condition, a mutated gene needs to be inherited from both parents for the condition to occur.

    Regardless of your results, you will have the opportunity to schedule an appointment with a genetic counselor.

  • What genes are covered in Admera Health’s Personal Portfolio?

    There are four genes covered in the Inherited Cholesterol test: APOB, LDLR, PCSK9, LDLRAP1.

    There are 29 gene covered in the Cardio Scout test: ACTA2, ACTC1, CASQ2, COL3A1, DSC2, DSG2, DSP, FBN1, GLA, KCNH2, KCNQ1, LMNA, MYBPC3, MYH11, MYH7, MYL2, MYL3, PKP2, PRKAG2, RYR2, SCN5A, SMAD3, TGFBR1, TGFBR2, TMEM43, TNNI3, TTN, TNNT2, and TPM1.

    There are 13 genes covered in the Inherited Diabetes test for MODY: ABCC8, BLK, CEL, GCK, HNF1A, HNF4A, INS, KCNJ11, KLF11, NEUROD1, PAX4, PDX1, and TCF2.

  • Why do I have to share some of my medical history before ordering a product?

    We partner with a national physician and genetic counselor network who provides medical oversight and genetic counseling. These physicians review your personal and family medical history to ensure you are receiving an appropriate test and may contact you as needed.

    Your medical history will not be shared with any additional party.

  • Will my medical history and results be shared with another party?

    We partner with a national physician and genetic counselor network who provides medical oversight and genetic counseling. These physicians review your personal and family medical history to ensure you are receiving an appropriate test and may contact you as needed.

    Your medical history will not be shared with any additional party.

  • Does a positive test mean I will definitely develop additional health problems?

    No, Admera Health’s Personal Portfolio DNA risk tests indicate that certain DNA changes create a risk for the disease. Environmental, biological and DNA factors effect whether DNA mutations express themselves in a clinical manner or create disease. The diagnosis of disease and all therapy for disease can only be made by your physician and additional DNA testing may be required based upon your risk profile.

    Admera Health offers a portfolio of diagnostic clinical tests that can be ordered by a physician that can provide a diagnosis. To learn more, visit: http://www.admerahealth.com/products/

  • What should I do if my results come back positive for likely pathogenic or known pathogenic mutation?

    If you are positive for one of the gene variants (mutations) screened for, you may be contacted by a board certified genetic counselor who will further explain your results to you. It is also strongly suggested that you seek out a specialist and follow-up with confirmatory medical testing. Admera Health offers a portfolio of clinical based genetic tests that could be helpful. You may also choose to talk about your results with family members that might also be at risk.

    You will have the opportunity to schedule an appointment with a genetic counselor.

  • I had a negative result. Does this mean I have no risk associated with these conditions screened for?

    No, the products within Admera Health’s Personal Portfolio are not all inclusive of all genes associated with risk for the specified condition(s). In addition, there are environmental and lifestyle factors that contribute to one’s risk for disease. Finally, scientific knowledge and the understanding of genetics changes over time. There may be variants in these tested genes whose contribution to disease in unknown at this time by determine to be disease causing in the future. Other genetic causes of disease might be identified as well.

    Based on your medical history, you may still choose to seek out a specialist and follow-up with confirmatory medical testing. Admera Health offers a portfolio of clinical based genetic tests that could be helpful. You may still choose to move forward with scheduling an appointment with a genetic counselor to discuss the implications of your results in more detail.

  • Can I learn any unexpected things from my test?

    Some of the gene variants (mutations) that these products look for may be associated with other diseases; however, Admera Health does not report gene variants that have an unknown significance at the time of testing.

  • I have undergone a bone marrow transplant; can I still take an Admera Health’s Personal Portfolio product?

    The saliva sample necessary includes DNA from multiple sources, including epithelial cells and white blood cells. If you have received a bone marrow transplant, the blood cells would have the donor’s DNA contaminating your sample and possibly be reflective in your results. This would not change your risk associated with the screened condition. Thus it is not recommended that you use an Admera Health’s Personal Portfolio product.

  • Will my results make it harder to get health insurance?

    The Genetic Information Nondiscrimination Act of 2008 (GINA), is a federal law that prohibits genetic discrimination in health insurance an employment. GINA makes it against the law for health insurers to request, or use genetic information to make decisions about eligibility for health insurance, insurance premium, contribution amounts, or coverage terms. GINA also makes it against the law for health insurers to consider family history or a genetic test result a pre-existing condition, ask or require that you have a genetic test, and use any genetic information they do have to discriminate against you.

    GINA does not pertain to long-term care, disability, or life insurance.

    To learn more about GINA, visit: http://ginahelp.org

  • Are Admera Health’s Personal Portfolio products covered by health insurance?

    Insurance companies do not pay for DNA screening of otherwise healthy individuals except under rare circumstances. Consumers now have an unprecedented opportunity to have DNA testing approved by a trained group of physicians versed in DNA testing with additional review by genetic counselors. With such risk information, the consumer themselves can bring results directly to their own doctor, usually a specialist, such as a cardiologist or endocrinologist, who can run further diagnostic testing if they feel appropriate based on the consumers risk profile results.

    Admera Health offers a portfolio of diagnostic clinical tests that can be ordered by a physician that are covered by insurance. To learn more, visit: http://www.admerahealth.com/products/

Admera’s Personal Health Portfolio is a member of the Helix marketplace





About Admera Health

Admera Health is an advanced molecular diagnostic company focused on personalized medicine and digital health. Dedicated to developing cutting-edge diagnostics that span the continuum of care, Admera Health fulfills unmet medical needs with cost-effective tests and accurate analysis to guide patient care. Genetic test results are delivered in a distilled and manageable report, providing the relevant information to make more informed healthcare decisions.

In addition to its partnership with Helix, Admera Health is a CLIA- and CAP-accredited laboratory providing its own clinical services.





CLIA- and CAP-accredited Laboratory

Your DNA analysis is being performed in a single CLIA-certified (Clinical Laboratory Improvement Act of 1986) and CAP-accredited (College of American Pathologists) U.S. laboratory.

A CLIA-accredited lab must meet established quality standards for all laboratory testing to ensure the accuracy and the reliability of results.

CAP is internationally recognized as the “gold standard” of laboratory accreditation programs with rigorous standards which meet or exceed CLIA regulatory requirements.





The Helix DNA Platform

Helix is a personal genomics company with a simple but powerful mission: to empower every person to improve their life through DNA. We’ve created the first marketplace for DNA-powered products where people can explore diverse and uniquely personalized products developed by highquality partners. Helix handles sample collection, DNA sequencing, and secure data storage so that our partners can integrate DNA insights into products across a range of categories, including ancestry, entertainment, family, fitness, health and nutrition. From profound insights to just-for-fun discoveries, Helix is here to help people live a fuller life. Helix is headquartered in the San Francisco Bay Area, and has a CLIA- and CAP-accredited Next Generation Sequencing lab powered by Illumina (NASDAQ:ILMN) NGS technology, in San Diego. Helix was founded in 2015 with support from Iillumina, its largest shareholder. Learn more at www.helix.com.

Helix, the Helix logo and Exome+ are trademarks of Helix Opco, LLC. All other trademarks referenced herein are the property of their respective owners.



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References

  1. Nordestgaard et al. Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease. European Heart Journal. Aug 2013. 34, 3478-3490
  2. Adabag A.S. et al. Sudden cardiac death: epidemiology and risk factors. Nat Rev Cardiol. April 2010; 7(4): 216-225
  3. Naylor R. et al. Who should have genetic testing for Maturity-onset Diabetes of the Young? Clin Endocrinol. 2011:75(4):422-426
  4. Kleinberger J. et al. Undiagnosed MODY: Time for Action. Curr Diab Rep. Dec 2015; 15(12):110